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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2014, Cilt 28, Sayı 3, Sayfa(lar) 117-121
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Effect of Varying Pre-Operative Doses of Lornoxicam on Postoperative Analgesia and Platelet Functions in Patients Undergoing Appendectomy
Selami Ateş ÖNAL1, Ayşe Belin ÖZER2, İsmail DEMİREL2, Ömer KAYMAZ3, Tuba GÖKDEMİR2, Ahmet DENİZ2
1Fırat Üniversitesi, Tıp Fakültesi, Algoloji Bilim Dalı, Elazığ, TÜRKİYE
2Fırat Üniversitesi, Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Elazığ, TÜRKİYE
3Kovancılar Devlet Hastanesi, Anestezi Kliniği, Elazığ, TÜRKİYE
Keywords: Lornoxicam, PT/INR, aPTT, appendectomy

Objective: In our study, it was examined the effect of 4, 8 or 16 mg i.v. lornoxicam administered 45 min. before surgery on postoperative analgesia and platelet functions in patients undergoing appendectomy.

Materials and Methods: Forty-two patients with an ASA risk status of I or II undergoing appendectomy were included in this randomised, double-blind, placebo-controlled study. The patients were divided into 3 groups according to lornoxicam dose: Group 4L: 4 mg; Group 8L: 8 mg; and Group 16L: 16 mg lornoxicam. Patients in Group C received 4mL of physiological saline instead of lornoxicam. Standart anaesthesia induction and maintenance were performed. In postoperative period, patient-controlled analgesia was provided with tramadol. Visual analogue scale scores were recorded at the time of admission to recovery room and at 1st, 2nd, 6th, 12th, and 24th postoperative hours. Also, the total dose of tramadol required was recorded at the end of the 24th postoperative hours. Two millilitres of venous blood sample was collected from patients at 24 pre- and post-operative hours to examine the platelet functions, aPTT, PT/INR value.

Results: There were no significant differences between the groups in terms of demographic characteristics. A higher VAS score and tramadol consumption was found in Group C (P<0.05). Pre- and post-operative aPTT and INR did not differ significantly between the study groups. increased aPTT in all groups and increased INR in Grup 16L were noted postoperatively (P<0.05)

Conclusions: Although increasing doses of lornoxicam seemed to result in an increase in INR without additional analgesia, further studies are warranted to reach a firmer conclusion.


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