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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2015, Cilt 29, Sayı 1, Sayfa(lar) 031-035
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The Effects of Perindopril, Novokinin and Losartan on Renin, AT1, AT2, ACE1, ACE2, Aldosterone on Renal Tissue in Experimental Hypertension Model Induced by L-NAME and Salt
Emre MUTLU1, Engin ŞAHNA2, Necip İLHAN3
1Ordu Üniversitesi, Tıp Fakültesi, Tıbbi Farmakoloji Anabilim Dalı, Ordu, TÜRKİYE
2Fırat Üniversitesi, Tıp Fakültesi, Tıbbi Farmakoloji Anabilim Dalı, Elazığ, TÜRKİYE
3Fırat Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Elazığ, TÜRKİYE
Keywords: Novokinin, renin angiotensin system, angiotensin type 2 receptor

Objective: In this study we investigated the effects of novokinin, an angiotensin type 2 (AT2) receptor agonist, on RAAS components such as renin, angiotensin converting enzyme 1 (ACE1), angiotensin converting enzyme 2 (ACE2), angiotensin type 1 (AT1) receptor,angiotensin type 2 (AT2) receptor, aldosterone which are associated with cardiovascular pathology. We compared the effects of AT1R antagonist losartan, ACE inhibitor perindopril and AT2R agonist novokinin on these parameters. We purposed to clarify how novokinin affects the parcipitant pathways which lead to renal damage, and we also evaluated whether novokinin is effective compared to other RAAS blockers.

Materials and Methods: L-NAME was administrated intraperitoneally, salt was given with drinking water (1%) for 4 weeks. Perindopril (2mg/kg/day), losartan (2 mg/kg/day), novokinin (0.1 mg/kg/day), were administrated intraperitoneally for the last 2 weeks. Renin, ACE1, ACE2, AT1R, AT2R, aldosterone were measured by ELISA in the renal tissue.

Results: In novokinin, perindopril and losartan-treated group ADE2 and AT2 receptor levels in the renal tissue showed a significant increase while there was a significant decrease in the level of aldosterone.

Conclusions: These findings have suggested that novokinin may exert a protective role in the renal injury. Further experimental studies are needed to exhibit potential benefits of AT2 receptor in hypertension and end organ damage.


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