Objective: The aim of the study is to assess the mean platelet volume (MPV) and platelet distribution width (PDW) in patients with unprovoked recurrent deep vein thrombosis (DVT).

Materials and Methods: Between January 2011-September 2017 patients with recurrent deep vein thrombosis at lower extremity were retrospectively examined and named as Group 1 (n: 30). The MPV and PDW values at the time of first deep vein thrombosis of these patients were compared with MPV and PDW values at recurring phase and also compared with patients’ MPV and PDW values in control group (Group 2, n: 30).

Results: The values of mean platelet volume in acute phase group compared with control group, a significant increased in patient group was detected (P= 0.002). MPV values in recurrent period were also higher compared to the control group (P<0.001). When values of MPV in acute and recurrent DVT period were compared, the values in recurrent period were found significanltly high (P<0.001). When PDW values are examined; patient group and control group were compared and it was seen that values in both acute and recurrent period were higher than control group and it was statistically significant (P<0.001).

Conclusion: The increased MPV and PDW values during platelet activation play a role at unprovoked acute and recurrent deep vein thrombosis. PDW is a more specific parameter than MPV; evaluation of MPV and PDW together may provide more effective consideration for venous thrombosis.