This study was aimed to investigate the effects of vitamin E and Coenzyme Q10 (CoQ₁₀) on lipid peroxidation, antioxidant profile and some biochemical parameters in the doxorubicin administered rats. 40 Wistar-Albino breed male, 6 months old rats were used. The animals were divided into four equal groups. The first group received doxorubicin (hydroxy daunorubicin) (2.5 mg/kg/week/i.p.). The second group was given CoQ₁₀ (4 mg/kg/daily/i.p.) in addition to doxorubicin. The third group received only CoQ₁₀ (4 mg/kg/daily/i.p.). The fourth group was dministered with vitamin E (10 mg (15 IU) /kg/subcutaneous/two times a week), in addition to doxorubicin. The study period was six weeks. The blood samples taken from the rats before the beginning of the experiment was used as the control group. At the end of the 6th- week, the blood samples were taken from all rats. As a result of the analysis, significant increases were observed in malondialdehyde and ceruloplasmin levels in all groups. Glutathione levels were decreased in all groups compared to the control group. No difference was observed in retinol and α-tocopherol levels. Significant decreases in albumin levels and significant increases in globulin levels were determined. Significant increases in total protein levels, significant increases in alanine aminotranferase levels in the DXR group, and decreases in other groups were observed. Significant decreases were observed in glucose levels. In the study, the oxidative effect of DXR was clearly seen, but the antioxidant effects of CoQ₁₀ and vitamin E were not observed at the desired level. According to the data of our study, it was concluded that antioxidant substances such as CoQ₁₀ and vitamin E can be used to reduce stress and damage caused by various drugs, but the duration of use of the given drugs may reduce the success of antioxidant substances.