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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2000, Cilt 14, Sayı 2, Sayfa(lar) 301-306
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Intracavernosal Injection of Vazoactive Agents For Treatment of Erectile Dysfunction: Comparison of Various Treatment Models
M. Kemal ATİKELER, Ertürk ERGİN
Fırat Üniversitesi Tıp Fakültesi, Elazığ-TÜRKİYE
Keywords: Intracavernosal Injection, Papaverine, PGE1 , Adenosine, Phentolamine, Trimix

Erectile dysfunction is a condition defined by the persistent inability to achieve or maintain an erection sufficient for satisfactory sexual performance. Intracavernosal injection of vazoactive agents is one of the method used for diagnosis and treatment of erectile dysfunction.

Between February 1999 and November 1999, 40 patients applied to the clinic because of erectile dysfunction without vascular causes were evaluated. Sixty mg papaverine(n=10), 15 µg PGE1 (n=10), 6 mg adenosine(n=10) and trimix including 22. 5 mg/ml papaverine, 8 µg/ml PGE1 , 0. 8 mg/ml phentolamine (n=10) were injected to 40 patients for observing the effect of intracavernosal vazoactive agents. They were evaluated physically after injection and erection starting time, erection period, degree and quality of erection and complications were noted.

No significant complication was observed during this study in 4 groups of patients. There was a statistically significant different between adenosine, PGE1 , papaverine, and trimix (p<0. 05)(p=0. 001) treatment groups. The most effective treatment was done with trimix. Effective results were also observed in PGE1 , papaverine and adenosine groups.

Finally, injection of intracavernosal vazoactive agent for treatment of erectile dysfunction without vascular causes seems a safe and effective treatment. Trimix appeared to be the most effective treatment option followed by PGE1 , phentolamine and papaverine treatments.


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