Vitamin K deficiency bleeding is rare in infants who received vitamin K prophylaxis at birth. We present a case of a 7-week-old infant with intracranial hemorrhage due to vitamin K deficiency bleeding, who received intramuscular vitamin K prophylaxis at birth. In his history, he had used a parenteral antibiotic four days ago. We noticed on that the use of an antibiotic may play a role in late vitamin K deficiency bleeding and it may be responsible for insufficiency of single dose vitamin K, administered at birth.