Pain is a complex and multi-dimensional experience. Pain is an experience which affects all individuals child or adult in physical, emotional, and social ways and which brings fear, anxiety, and depression with it. For this reason, it is important to determine and evaluate the pain conditions of newborns urgently. Acceptable nursery approaches can be developed by examining physiological and behavioral variables, metabolic parameters, and hormone levels at pain. All health professionals are responsible for examining, removing, or reducing pain. The analgesics used for reducing the perception of pain are more effective when they are used with non- pharmacological techniques. The proof referenced application examples (kangaroo care, breast feeding, lactation, sucrose, position change, music, etc.) used by health professional independently is discussed in this article.