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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
1999, Cilt 13, Sayı 1, Sayfa(lar) 037-040
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The Histopathologic Effects Of Inhaled Formaldehyde On Leydig Cells Of The Rats In Subacute Period
Mustafa SARSILMAZ, Oğuz Aslan ÖZEN, Nusret AKPOLAT, İlter KUŞ, Ahmet SONGUR
Fırat Üniversitesi, Tıp Fakültesi, Elazığ / TÜRKİYE
Keywords: Formaldehyde; inhalation; leydig; subacute

This study was planned to research effects of subacute formaldehyde exposure on Leydig cells in the rat, since literature on this subject is limited.

Adult male wistar rats were exposed for 4 weeks (8 h/day; 5 days/week) to 0 (control), 10 and 20 ppm formaldehyde vapour. Gradual diminution in body weight gain and Leydig cell population was observed in both test groups. Various types of nuclear damage in Leydig cells was quantitatively determined in the experimental groups. Subacute inhalation of formaldehyde vapour caused structural impairement of Leydig cells.

These adverse effects on the rat Leydig cells inhaled formaldehyde have shown that other body organs except respiratory system should be investigated by researchs in different times and concentrations.


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