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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi |
2012, Cilt 26, Sayı 2, Sayfa(lar) 091-092 |
[ Turkish ] [ Tam Metin ] [ PDF ] |
Acute Systemic Toxicity in a Patient After a Single Dose of Diclofenac |
Ali GÜREL1, Deccane DÜZENCİ2, Bilge AYGEN1, Ayhan DOĞUKAN1 |
1Fırat Üniversitesi, Tıp Fakültesi, Nefroloji Bilim Dalı, Elazığ, TÜRKİYE 2Fırat Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Elazığ, TÜRKİYE |
Keywords: Hemolysis, acute liver failure, acute renal failure, diclofenac |
Non steroid antiinflammatory drugs (NSAIDs) have been known to be a cause of acute hemolytic
anemia, acute hepatic failure and acute renal failure for a long time. We report a 50 years old
woman with lomber disc hernia who had been injected a single dose diclofenac sodium because of
lomber pain and afterwards in 24 hour period observed deterioration in general health status. Her
bichemical evaluation was consistent with acute hemolysis, acute hepatic injury and acute renal
failure. After supportive therapy her general health status and biochemical parameters started to
ameliorate and on the twentyfirst day of administration the patient was discharged with normal
hematologic, liver and kidney parameters. It should be remembered by the clinicians that NSAIDs
can cause multisystemic toxicities as hemolytic anemia, liver disfunction and kidney failure. Hence,
immediate therapeutic interventions after the diagnosis can be life-saving.
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