Non steroid antiinflammatory drugs (NSAIDs) have been known to be a cause of acute hemolytic anemia, acute hepatic failure and acute renal failure for a long time. We report a 50 years old woman with lomber disc hernia who had been injected a single dose diclofenac sodium because of lomber pain and afterwards in 24 hour period observed deterioration in general health status. Her bichemical evaluation was consistent with acute hemolysis, acute hepatic injury and acute renal failure. After supportive therapy her general health status and biochemical parameters started to ameliorate and on the twentyfirst day of administration the patient was discharged with normal hematologic, liver and kidney parameters. It should be remembered by the clinicians that NSAIDs can cause multisystemic toxicities as hemolytic anemia, liver disfunction and kidney failure. Hence, immediate therapeutic interventions after the diagnosis can be life-saving.