Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi |
1999, Cilt 13, Sayı 1, Sayfa(lar) 065-070 |
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Pharmacological Characteristics And Physiological Roles Of Calcium-Activated Chloride Conductance In Neurons |
Ahmet AYAR, Kadir SERVİ |
Fırat Üniversitesi, Tıp Fakültesi, ELAZIĞ / TÜRKİYE |
Keywords: Calcium-activated chloride channels, chloride channel inhibitors, neurone |
Neuronal cell membranes contain several ligand and voltage-gated ion channels. The type and location of these ion channels determines the electrical behaviour of a neurone. Sodium, potassium, chloride and calcium channels are among the main ion channels that present in cell membranes. Some of these channels are also activated by calcium; the calcium-activated chloride, calcium-activated potassium and calcium-activated non-selective cation channels are among the main Ca2+-dependent ion channels of cell membranes. In this review, we discuss some of the pharmacological, biophysical properties and possible physiological roles of calcium-activated chloride channels in neurons.
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