Traumatic reticuloperitonitis (TRP) is a disease caused by sharp foreign objects in the reticulum. When the reticulum wall is punctured, localized peritonitis may first develop, followed by acute diffuse peritonitis. The study consisted of control and TRP groups, with 10 cows in each group belonging to various breeds and their crossbreeds. Haptoglobin (Hp), neopterin (NPT) and procalcitonin (PCT) values were determined to be significantly higher in the TRP group compared to the control group (p<0.001, p<0.01, p<0.001, respectively). It was observed that malondialdehyde level was significantly higher in the TRP group (p<0.001) but superoxide dismutase was significantly lower (p<0.001). No significant differences were observed between the groups with respect to catalase values (p>0.05). Haematological indices were investigated in the study, revealing significantly higher values for total leukocytes, neutrophils and neutrophil-lymphocyte ratios in the TRP group compared to the control group (p<0.001). As a result, this study showed that PCT and NPT along with Hp gave valuable results in determining the inflammatory status in TRP disease, and significant results were obtained in oxidative stress and hematological parameters.