In this study, the effects of zingerone were investigated in a Bisphenol A (BPA)-induced experimental hepatorenal toxicity model. For this purpose, 24 Wistar albino rats were randomly divided into 4 groups. The groups were assigned as follows; Control; dimethyl sulfoxide (DMSO), BPA (Bisphenol A 25 mg/kg), Zingerone (50 mg/kg), BPA+Zingerone (Bisphenol A 25 mg/kg + Zingerone 50 mg/kg). The study continued for 30 days for all animals. At the end of the study, biochemical parameters such as, malondialdehyde (MDA), reduced glutathione (GSH), glutathione peroxidase (GSH.Px), catalase (CAT) and serum biochemical parameters aspartate aminotransferase (AST), alanine transaminase (ALT), urea, creatinine, C-reactive protein (CRP) were examined in the liver and kidney tissues of the animals. Results showed that while the MDA level in liver and kidney tissues increased significantly with BPA application (p<0.001), in the BPA+Zng group it reached the same levels as the control group (p<0.001). While liver and kidney tissue GSH.Px activities similarly decreased with BPA application (p<0.01), it was determined that in the BPA+Zng group it reached the same levels as the control group. When serum biochemical parameters are examined; with BPA application, AST (p<0.01), ALT (p<0.05), urea (p<0.01) and creatinine (p<0.05) levels increased. However, it was determined that serum urea (p<0.01) and creatinine (p<0.05) levels in the BPA+Zng group reached the same levels as the control group. As a result, BPA application increased oxidative stress in the liver and kidney tissues, decreased antioxidant activity, and had negative effects on serum biochemical parameters. However, Zingeron reduces oxidative stress and has healing effects on serum biochemicals such as urea and creatinine.