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Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi
2024, Cilt 38, Sayı 3, Sayfa(lar) 246-251
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The Polymorphism of Insulin-Like Growth Factor-1 Receptor Gene and Its Associations with Live Weight Traits and Birth Type in Akkaraman Lambs
Merve YÜKSEL1, Davut BAYRAM2, Korhan ARSLAN3, Fadime DALDABAN3, Mehmet Ulaş ÇINAR4, Bilal AKYÜZ3
1Fırat University, Faculty of Veterinary Medicine, Department of Genetics, Elazığ, TÜRKİYE
2Erciyes University, Faculty of Veterinary Medicine, Department of Animal Breeding and Husbandry, Kayseri, TÜRKİYE
3Erciyes University, Faculty of Veterinary Medicine, Department of Genetics, Kayseri, TÜRKİYE
4Erciyes University, Faculty of Agriculture, Department of Animal Science, Kayseri, TÜRKİYE
Keywords: Weight, Birth type, IGF1R, PCR-RFLP, Sheep

The insulin-like growth factor 1 receptor (IGF1R) gene is a potential candidate gene as it is involved in several physiological processes related to yield charecteristics. We conducted this study to investigate a polymorphism (g.195C>T) in the IGF1R gene, identified using the Rsal enzyme, and its associations with live weight gain from birth to weaning and birth type in the Akkaraman sheep breed. A total of 397 male Akkaraman breed lambs were examined. The samples analyzed have revealed three distinct genotypes (AA, AB, BB) in terms of the g.195C>T polymorphism as a result of the utilized polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). As a result of Chi-square analysis using genotypic data, it was determined that the examined samples were not in Hardy-Weinberg equilibrium for IGF1R-Rsal polymorphism. Throughout the growth period from birth to 90 days, slight differences in growth rates were observed due to the effects of birth type and IGF1R genotypes. However, these differences were not statistically significant across genotypes in terms of live weight gain. Additionally, it was observed that the BB genotype had a higher frequency in single-born lambs, and there was a statistically significant relationship between IGF1R-Rsal polymorphism and lamb birth type (p<0.01). The results have considered that it was necessary to suggest that new studies might be planned to investigate the relationship between IGF1R-Rsal polymorphism and other yield characteristics, especially birth type, in sheep.

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