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Fırat University Journal of Health Sciences (Veterinary)
2025, Cilt 39, Sayı 2, Sayfa(lar) 113-121
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Protective and Preventive Role of Folic Acid Against Ivermectin-Induced Renal Toxicity
Ender ERDOĞAN1, Özge KANDEMİR2, Nurhan AKARAS3, Hasan ŞİMŞEK4, Fatih Mehmet KANDEMİR5
1Atatürk University, Faculty of Veterinary, Department of Veterinary Biochemistry, Erzurum, TÜRKİYE
2Aksaray University, Aksaray Technical Sciences Vocational School, Department of Food Processing, Aksaray, TÜRKİYE
3Aksaray University, Faculty of Medicine, Department of Histology and Embryology, Aksaray, TÜRKİYE
4Aksaray University, Faculty of Medicine, Department of Physiology, Aksaray, TÜRKİYE
5Aksaray University, Faculty of Medicine, Department of Medical Biochemistry, Aksaray, TÜRKİYE
Keywords: Apoptosis, folic acid, ınflammation, ivermectin, nephrotoxicity

In addition to its widespread use as an antiparasitic in human and animal health, ivermectin (IVR) has been extensively investigated for its therapeutic use against the disease during the Covid-19 pandemic and its positive effects have been reported. Folic acid (FA) plays an important role in the protection of the nervous system, the formation of healthy red blood cells, the synthesis and repair of DNA and other genetic materials, and the division process of cells. As a small molecular weight compound, FA is freely filtered by the glomerulus. The aim of this study was to investigate the protective and preventive role of FA against IVR-induced renal toxicity. In this study, biomarkers that cause kidney toxicity, apoptosis and lipid peroxidation were evaluated. In the IVR+FA group, compared to the control group; urea, creatinine, malondialdehyde, interleukin-17A, nuclear factor kappa-B, Tumor necrosis factor-α, caspase-3, Bcl-2–associated X protein and kidney injury molecule-1 values were found higher, while glutathione, superoxide dismutase, catalase, glutathione peroxidase, B cell lymphoma-2 and aquaporin-2 values were found lower. Increases were observed in biomarkers causing kidney toxicity, apoptosis and lipid peroxidation in the IVR group. These results showed that FA protects against IVR nephrotoxicity.

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