The aim of this study was to investigate the protective effects of boric acid on uterine ischemia-reperfusion (IR) injury in rats. Twenty-four female rats were randomly divided into 3 groups. In the sham group, only laparotomy was performed. In the second group (IR), experimental ischemia (45 min) and reperfusion (1 hour) were induced. In the third group (BA+IR), boric acid was administered intraperitoneally at a dose of 200 mg/kg, 10 minutes before ischemia. Afterwards, uterine tissue was subjected to reperfusion for 1 hour. After the reperfusion period, the uterine tissues were surgically removed and fixed in formalin solution. Histopathological evaluation revealed significant differences in tissue damage among the groups (p<0.0001). The IR group exhibited marked edema, congestion, inflammation, necrosis and endometrial injury compared to the sham group (p<0.0001). In contrast, boric acid treatment significantly reduced these pathological changes. No significant histological difference was observed between sham and boric acid groups (p˃0.05). In conclusion, boric acid treatment demonstrated a protective effect against uterine IR injury and contributed to the preservation of endometrial health. These findings suggest its potential as a fertility-preserving agent in uterine ischemia.