Chemotherapy treatment of very common oral papillomatosis in a 7-month male dog(pointer) and clinical outcomes of the treatment were presented in this case. The case was successfuly treated by the administration of intravenous cyclophosphamide IV (3-6 mg / kg ) 4 times every two weeks. As a result it was understood that chemotherapy could be used as an effective method in case of wide and acute oral papillomatosis.