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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2015, Cilt 29, Sayı 2, Sayfa(lar) 079-086
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Diffusion MRI Findings in Patients with Obsessive-Compulsive Caudate Nucleus and Putamen
Selami SERHATLIOĞLU1, Cemil DAŞ2
1Fırat Üniversitesi, Tıp Fakültesi, Radyoloji Anabilim Dalı, Elazığ, TÜRKİYE
2Iğdır Devlet Hastanesi, Radyoloji Kliniği, Iğdır, TÜRKİYE
Keywords: Parkinson disease, substantia nigra, diffusion weighted magnetic resonance imaging

Objective: The purpose of this study is to reveal the findings of substantia nigra in Parkinson's patients by diffusion-weighted magnetic resonance imaging (DA-MRI) and to compare the results with a control group.

Materials and Methods: The study included 20 patients with Parkinson disease and 20 healthy volunteers. In these cases, diffusion-weighted magnetic resonance imaging (DW-MRI) and diffusion weighted echo-planar images (DW-EPI) at b100, b600 and b1000 gradient values were taken and the measurements were made through the maps of apparent diffusion coefficient (ADC) of each group at b100, b600 and b1000 values from substantia nigra.

Results: Mean ADC values at b100 for the control group were found as 125±30 x10-4 mm²/sec in substantia nigra and these values at b100 for patients with Parkinson disease were found as 100±44 x10-4 mm²/sec. For b600, 78±16 x10-4 mm²/sec were found in control group and 70±14 x10-4 mm²/sec patients with Parkinson disease. For b1000 60±14 x10-4 mm²/sec were found in control group and 58±8 x10-4 mm²/sec patients with Parkinson disease.

Conclusions: When DW-MRI examination in patients with Parkinson disease was compared with control group, changes at mean ADC values for b100 in substantia nigra were found statistically significant. However, there were no significant changes at ADC values for b600 and b1000 in substantia nigra at patients with Parkinson disease and control group.


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