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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2019, Cilt 33, Sayı 1, Sayfa(lar) 043-046
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Evaluation of Platelet İndex and Biochemical Parameters in Patients with Hepatitis B Virus
Umut Safiye ŞAY COŞKUN1, Zeliha Cansel ÖZMEN2
1Tokat Gaziosmanpaşa University, Faculty of Medicine, Department of Medical Microbiology, Tokat, TURKEY
2Tokat Gaziosmanpaşa University, Faculty of Medicine, Department of Medical Biochemistry, Tokat, TURKEY
Keywords: Pregnancy, Hepatitis B, platelet index, biochemical parameters, platelet -large cell ratio

Objective: The clinical importance of thrombosis in Hepatitis B virus (HBV)-related liver diseases has been demonstrated in many studies. In addition, it was shown that inflammation of the liver is associated with lipid metabolism disorder. The aim of this study was to determine the platelet index and biochemical parameters in HBV-DNA positive and HBV-DNA negative patients for investigating whether these parameters are contributing in the follow-up of Hepatitis B patients.

Materials and Methods: In this study, results of 54 HBV–DNA positive and 54 HBV–DNA negative patients with chronic Hepatitis B between January 2016 and December 2017 at Tokat Gaziosmanpasa University Medicine Faculty Hospital Microbiology Laboratory were evaluated retrospectively. Aspartat aminotransferaz (AST), alanin aminotransferaz (ALT), low density lipoprotein (LDL) parameters were detected by COBAS 6000 (Roche Dianostic, France) device with spectrophotometric method. Platelet (PLT), mean platelet volume (MPV), platelet-large cell ratio (P-LCR) were measured by Sysmex XN 1000 (Sysmex Corporation, Kobe, Japan) complete blood count device. Student t test and one-way ANOVA test were used for comparison between groups. P<0.05 was considered statistically significant.

Results: In this study, there were a statistically significant increase in AST, ALT, LDL, MPV and P-LCR levels compared to the control group in both HBV-DNA positive and HBV-DNA negative patients. However there was a statistically significant decrease in PLT levels (P<0.05).

Conclusion: Our results show that the parameters of AST, ALT, LDL, PLT, MPV and P-LCR are easy to operate and cost-effective for both the disease and the course of treatment. P-LCR should be considered as a part of the parameter of platelet index may contribute to the clinician in the follow-up of Hepatitis B infection.


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