[ Ana Sayfa | Editörler | Danışma Kurulu | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | E-Posta ]
Fırat University Journal of Health Sciences (Veterinary)
2021, Cilt 35, Sayı 1, Sayfa(lar) 001-006
[ Turkish ] [ Tam Metin ] [ PDF ]
Determination of In vitro and In vivo Biocompability of Hydroxyapatite Based Bioceramic Materials
Mustafa KÖM1, Okan ERKMEN2, Eren POLAT1, Ömer KAYGILI3, Yesari ERÖKSÜZ4
1Fırat Üniversitesi, Veteriner Fakültesi, Cerrahi Anabilim Dalı, Elazığ, TÜRKİYE
2Tarım ve Orman Bakanlığı, Elazığ İl Müdürlüğü, Elazığ, TÜRKİYE
3Fırat Üniversitesi, Fen Fakültesi, Fizik Bölümü, Elazığ, TÜRKİYE
4Fırat Üniversitesi, Veteriner Fakültesi, Patoloji Anabilim Dalı, Elazığ, TÜRKİYE
Keywords: Hydroxyapatite, bone defect, rat

The reconstruction of large bone defects can not self-repair and needs bone grafts. It was aimed at investigating in vitro and in vivo biocompability of hydroxyapatite (HAp) based bioceramic materials that we produced.

In this study, 42 Spraq dawley rats were used for in vivo study. Rats divided into 3 groups equally. After general anesthesia, rats were drilled 2 defect of 2 mm on the upper poximal metaphysis of tibia. In the first group bone defect were left to heal by themselves without using any material. Bone defect were reconstructed with HAp material in the second group. Third group were filled with commercial HAp. Operation wounds were closed using routine surgery. The rats were sacrificed at the postoperative of 14th or 28th days. Histopathologicaly, It was observed that the HAp produced was in the ossicification process.

As a result, we need long term and more detailed examinations for evaluation of hydroxyapatite based bioceramic materials.


[ Turkish ] [ Tam Metin ] [ PDF ]
[ Ana Sayfa | Editörler | Danışma Kurulu | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | E-Posta ]