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Fırat University Journal of Health Sciences (Veterinary)
2021, Cilt 35, Sayı 1, Sayfa(lar) 007-012
[ Turkish ] [ Tam Metin ] [ PDF ]
Effect of Hyaluronic Acid on Adhesion and Tendon Healing in Rats
Mustafa KÖM1, Eren POLAT1, Oktay YİĞİT2, Fatih BÜYÜK3, İlknur ÇALIK4
1Fırat Üniversitesi, Veteriner Fakültesi, Cerrahi Anabilim Dalı, Elazığ, TÜRKİYE
2Fırat Üniversitesi, Teknoloji Fakültesi, Metalurji ve Malzeme Mühendisliği, Elazığ, TÜRKİYE
3Havza Belediyesi, Hayvan Hastanesi, Samsun, TÜRKİYE
4Fırat Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, ELAZIĞ, TÜRKİYE
Keywords: Hyaluronic acid, adhesion, tendon healing, rat

Adhesion and tendon rupture are one of the problems after tendon injuries in human and veterinary medicine. In this study, it was aimed to demonstrate the effect of repeated hyaluronic acid (HA) applications macroscopically, biomechanically and histopathologically.

Thirty spraq dawley rats, 6 months old, were used in the study. The rats which was created after primary tendon repair in achilles tendons were randomly divided into three groups. The first group were evaluated as the control group and no treatment was applied after the operation. In the second group, 0.075 ml/kg HA was applied around the tendon as a single dose after the operation. In the third group, the same dose of HA was applied around the tendon on the 3rd, 7th and 14th days after the operation. After scarification, in the macroscopic, biomechanical and histopathological evaluations, it was observed that there was less adhesion in the treatment groups compared to the control group. As a result of the macroscopic evaluation, it was determined that the adhesion degree of the treatment groups was significantly lower than the control group (P<0.05). There was no significant difference between 2nd and 3rd groups, which are the treatment groups (P>0.05). The degree of inflammation was found significantly lower in the 3rd group who received repeated HA administration (P<0.05). There was no difference between the groups in terms of neovascularization, fibroblastic proliferation and fibrosis (P>0.05). Biomechanically, maximum force to rupture in group 3 were higher in control group and group 2.

In conclusion, it was determined that HA applications are useful treatment options to prevent adhesions that may occur during surgical treatments performed after tendon injuries. It was concluded that detailed studies should be carried out regarding the application of HA in single or repeated doses during tendon healing.


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