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Fırat University Journal of Health Sciences (Veterinary)
2021, Cilt 35, Sayı 1, Sayfa(lar) 027-032
[ Turkish ] [ Tam Metin ] [ PDF ]
Evaluation of the Effects of Ankaferd Blood Stopper on the Healing of Experimental Skin Wounds in Rats
Aydın SAĞLIYAN1, Cihan GÜNAY1, Ali Said DURMUŞ1, Mustafa KÖM1, Esra KİRMAN2, Yasin BAYKALIR3
1Fırat Üniversitesi, Veteriner Fakültesi, Cerrahi Anabilim Dalı, Elazığ, TÜRKİYE
2Atatürk Üniversitesi, Veteriner Fakültesi, Patoloji Anabilim Dalı, Erzurum, TÜRKİYE
3Fırat Üniversitesi, Veteriner Fakültesi, Zootekni Anabilim Dalı, Elazığ, TÜRKİYE
Keywords: Ankaferd blood stopper, madecassol, wound healing, rat

In this study, the effects of Ankaferd Blood Stopper (ABS), a folkloric medicinal plant extract used as a haemostatic agent in traditional Turkish medicine, on wound healing of experimental standard full-thickness skin defects were analysed. A total of 36 rats were used in the study. Skin wounds were created by 5 mm punch biopsy knots on the back of all rats. The rats were divided into 3 groups with 12 rats in each group. While the rats in group 1 were applied ABS solution twice a day locally, and the rats in group 2 madecassol twice a day, no treatment was applied to the rats in group 3. On the 7th and 14th days of the study, six rats in each group were euthanized and macroscopic measurements of the wound areas were made. The wound areas in group 1 and 2 healed faster than group 3, but there was no significant difference. For histopathological examinations, tissue samples were taken at the wound site and epithelization, granulation tissue formation and inflammatory cell infiltration were evaluated. A statistically significant difference was found between the groups in the histopathological evaluations. As a result, it has been concluded that ABS, which is a natural product, is a safe drug, does not have any negative effect on wound healing and can be used effectively and safely in full-thickness skin wounds. However, additional studies are needed to evaluate the clinical and histopathological benefits and possible negative effects of ABS on wound healing.

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