Introduction: Rhabdomyolysis is a complex medical condition that develops as a result of the release of damaged skeletal muscle cell contents into the circulation and sometimes has life-threatening consequences. Trauma, drugs, toxins, infections, metabolic abnormalities, heat-related conditions, prolonged inactivity and excessive exercise may be among the causal factors.

Case Report: We present an elderly female patient who developed rhabdomyolysis due to a rare reason: Rhabdomyolysis secondary to acute quadriparesis secondary to brain edema associated with intracranial mass lesions.

Conclusion: Rhabdomyolysis may be a rare complication due to acute quadriparesis resulting from neurological pathologies. Since rhabdomyolysis can have life-threatening consequences, early diagnosis and treatment by clinicians is important.