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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2021, Cilt 35, Sayı 2, Sayfa(lar) 097-101
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The Effect of Raloxifene and Fluoxetine Treatment on Oxidant-Antioxidant Status in Breast Cancer Bearing Rats
Necip İLHAN1, Oguzhan TATAR1, Solmaz SUSAM2, Nevin İLHAN1
1Fırat University, Faculty of Medicine, Medical Biochemistry Department, Elazig, TURKIYE
2Adiyaman University, Faculty of Medicine, Medical Biochemistry Department, Adiyaman, TURKIYE
Keywords: Antioxidant enzymes, breast cancer, CA 15-3, DMBA, MDA

Objective: 7,12-Dimethylbenz[a]anthracene (DMBA)-induced tumors in mammary tissue closely mimic human breast cancer in morphology and the expression of biochemical and molecular markers. Although significant advances have been seen in the treatment of breast cancer, there is still a great need for alternative approaches. The current experiment was designed to investigate the therapeutic effect of Raloxifene (RAL) and Fluoxetine (FLX) by assessing oxidant and antioxidant parameters in DMBA-induced breast carcinogenesis in rats.

Materials and Methods: Thirty-two female Wistar rats were divided into 4 groups. Group I was treated only DMBA. After tumor induction, cancer bearing rats were orally treated with RAL (Group II), with FLX (Group III), and finally with RAL+FLX (Group IV), respectively. Tumors were induced in the whole groups using DMBA dissolved in olive oil (80 mg/kg body weight). The tumor marker cancer antigen (CA) 15-3 and selected oxidative and antioxidative parameters were analyzed in whole experimental groups by using appropriate methods.

Results: The oral treatment of the therapeutic agents alone or in combination provided a significant decrease in CA 15-3 levels in all therapeutic groups compared to DMBA group. When the level of malondialdehyde was measured, it was noticed a decrease in all treatment groups compared to the DMBA group. Additionally, the activities of enzymatic antioxidants were renovated to better after supplementation with the therapeutic agents, suggesting that this agents exhibiting anticancer effect.

Conclusion: It was proposed that the combination of RAL and FLX was more effective than each of RAL or FLX alone on restoration devastating effects of breast cancer.


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