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Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi
2001, Cilt 15, Sayı 2, Sayfa(lar) 387-396
[ Turkish ]
COMPARISON OF THE EFFECTIVENESS OF HYALURONIC ACID, PREDNISOLONE AND DOXYCYCLINE ON THE PROGRESSION OF THE POND-NUKI MODEL OF OSTEOARTHRITIS IN DOGS
KILIÇ, S., KARADAŞ E. , İSTEK Ö., TİMURKAAN, N.
Fırat University. Veterinary Faculty, . Elazığ / TÜRKİYE
Keywords: Dog, Osteoarthritis, Prednisolon, Hyaluronic Acid, Doxcycline.

The purpose of this study was to evaluate the benefit of Hyaluronic Acid (HA), prednisolone and doxycycline on OA which was induced experimentally by ACLT bilaterally in 3 and unilaterally in 9 crossbred dogs. While the left stifle joints of 3 cases with bilateral ACLT were used as control (group 1) their right joints were given intraarticularly 0.7 ml HA (group 2) with one week intervals. The remaining 9 dogs were equally allocated to 3 groups termed groups 3, 4 and 5. Group 3 cases received intraarticularly 5 mg prednisolone per week and groups 4 and 5 cases orally 0.25 mg/kg/day prednisolone and 50 mg b.i.d doxycycline, respectively. The treatment started 5 weeks after surgery and continued for 7 weeks. During intaarticular examination of the euthanized cases, the synovial thickness appeared to be greater in group 2 than group 1 cases whose synovial thickness was than other three group cases. Although statistically non-significant (P> 0.05), the degree of the synovitis increased successively as groups 3, 5, 4, 2 and 1. The joint surfaces of group 1 cases contained ulcerations bigger that those of experimental groups. In this respect, there was no difference between experimental groups. According to the histologic data, the degree of the cartilage degradation was found to increase sequentially as groups 2, 5, 3, 4, and 1. It was determined from both morphologic and quantitative results that OA tended to progress more slowly in groups 2 than group 5 which was successively than groups 3, 4 and 1. Doxycycline like HA and prednisolone appears to have an anti-arthritic feature as compared to control. In this respect, it was concluded to be used as an alternative to other two drugs.

[ Turkish ]
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