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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2000, Cilt 14, Sayı 2, Sayfa(lar) 281-286
[ Turkish ] [ PDF ]
Investigation of Relationship Between Serum Beta Endorphine and Gonadotropic Hormones Levels Secretion Profiles In Pro-Oestrus Rats
Selahattin KUMRU, Ekrem SAPMAZ
Fırat Üniversitesi Tıp Fakültesi, Elazığ-TÜRKİYE
Keywords: :b-endorphine, FSH, LH surge, Pro-östrus

Beta endorphine levels are high in subjects like athletes who are involved in intense physical activity and in hypothalamic amenorrhea cases. Additionally, levels of b-endorphine in hypophyseal portal system are found to be varied in different phases of oestrus cycles. With the lights of these knowledges in the present study we aimed to investigate the relationship between serum Luteinizan Hormone (LH), Follicle Stimulating Hormone (FSH) and b-endorphine levels in serum at the day of pro-oestrus. For this purpose total of 22 Wistar albino rats were decapitated at 09.00 am (n=7), 11.00 am (n=8) and 13.00 pm (n=7) and LH, FSH and b-endorphine levels in the serum was determined. One Way ANOVA (MINITAB for Windows) was used for statistical analysis of the data. The serum b-endorphine levels of groups sacrified at 09.00am, 11.00 am and 13.00 pm was 8.90±4.91, 10.27±7.8 and 3.27±2.66 fg/ml, respectively; the LH levels of groups was 0.34±0.04, 0.34±0.03 and 0.40±0.04 ng/ml respectively, and the FSH levels was 4.20±0.71, 4.44±0.34 ve 4.21±0.27 ng/ml respectively. It was found that b-endorphine levels was significantly reduced at 13.00 compared to those sacrified at 09.00 am (p<0.05) and in LH there was a modest increase that was not statistically significant. There was no difference between the FSH levels. It was concluded that decreased opioid activity might be contrubuting to the pro-oestrus LH surge secretion and FSH is under the control of other factor(s).

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