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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2005, Cilt 19, Sayı 4, Sayfa(lar) 277-281
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The Relationship Between Plasma Vascular Endothelial Growth Factor, Oxidative Stress and Nitric Oxide in Patients With Prostate Cancer and Benign Prostatic Hyperplasia
Dilara SEÇKİN1, Rahmi ONUR2, Nevin İLHAN1, Aslan ARDIÇOĞLU2, Necip İLHAN1
1Fırat Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Elazığ – TÜRKİYE
2Fırat Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, Elazığ – TÜRKİYE
Keywords: Malondialdehyde, Nitric Oxide, Vascular Endothelial Growth Factor

In the present study, the role of plasma vascular endothelial growth factor (VEGF) and its association with oxidative stress and nitric oxide (NO) was evaluated in patients with benign prostatic hyperplasia (BPH) and prostatic carcinoma (PCa). The plasma VEGF levels in patients with prostatic carcinoma were significantly higher than in patients with BPH (61.98+14.62 pg/ml vs 38.63+ 12.74 pg/ml, p<0.05). Increased VEGF levels was detected concomitantly with increased plasma malondialdehyde (MDA) and NO levels in patients with PCa. Our results demonstrated the close relation between the angiogenic stimuli, oxidative stress and NO expression, which may be several of the contributing factors in the pathogenesis and disease status of malignant prostate. We believe that our data support further study of antiangiogenesis and antioxidant strategies for the treatment of human prostate cancer.

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