This experiment was conducted to determine the effect of vitamin E (dl-alpha-tocopherol acetate) on healing of radial diaphysis fracture in dogs.

Eighteen adult (mean 3 -y-old), mongrel female dogs were divided into two equal groups. Fixation was performed with bone plate after fracture constituted on radial diaphysis. Postoperatively, dl-alpha-tocopherol acetate (20 mg/kg/day) was injected intramuscularly to the first group (treatment group) for one week. The second group was kept as control group. The result of the study was evaluated clinical and radiographically on postoperative days of 15th, 30th and 60th. At each examination time tissue samples of three cases of each group were harvested and these cases were freed.

Dl-alpha-tocopherol acetate being more effective in early stages (first fifteen days) was evaluated due to its antioxidant effect on free oxygen radicals in the fracture region. Consequently, it was understood that dl-alpha-tocopherol acetate given for a week had a positive effect on the fracture healing in dogs in case of applying immediately (in early stages).