In this study, cecal dilatation-dislocation and torsion diagnosed using laparotomy technic in three Holstein cows with the ages of 5 (first case), 7 (second case), and 8 (third case) years, respectively, were evaluated. The animals were brought to the clinics of the Faculty of Veterinary Medicine, Mustafa Kemal University, one month later after parturition, with the complaints of anorexia, restlessness, weight loss, and decreased milk production. In clinical examination; dehydration at varying levels was observed in all cases. Simultaneous auscultation and percussion revealed ping sounds in right abdomen. The levels of serum Na⁺, K⁺, Cl^-, Ca⁺² and P^-3 were determined to decrease, while creatinine levels increased. Experimental laparotomy through the right paralumbar fossa disclosed necrosis in the mesentery of the region of the ileo-seco-colic torsion. Thus, perforation was seen in the first and second cases. As treatment; cecal content was evacuated, the torsions were corrected, and the perforated necrotic areas were resected and sutured. The second and the third cases recovered but the animal in the first case was sent to slaughter due to deterioration during the post-operative period. As a result, the priority of medical or surgical treatment should be based on the changes in clinical and laboratory findings in the cases of cecal dilatation, dislocation and torsion. Additionally, it is concluded that reduced iron level may be considered as a prognostic indicator observed in the cases with dehydration, gastrointestinal bleeding, and anemia.