Objective: Most frequently isolated pathogens are staphylococcus aureus (S. aureus) and streptococcus pyogenes. This study was performed to determine the most common cause of bacterial skin infections and to compare the results of antimicrobial sensitivity against isolated microorganisms and the empirical antibiotics used to treat bacterial skin infections.

Materials and Methods: This study was performed with 38 patients who were diagnosed as bacterial skin infection in Dermatology and Infectious Diseases outpatient clinic of Firat University Hospital. The samples were inoculated onto (5%) Sheep Blood Agar and Eosin Methylene Blue Agar. Catalase and coagulase test was performed for isolated Gram positive bacteria after incubation at 37 ° C for 18 to 24 hours. Catalase and coagulase tests were applied to Gram positive bacteria. Antimicrobial sensitivity tests were performed according to the Clinical and Laboratory Standards Institute recommendations by the Kirby-Bauer disk diffusion method.

Results: The most common isolated microorganism was S. aureus (29%). Most common antibiotics were ampicillin / sulbactam (29%), amoxicillin-clavulanate (26.3%) and fusidic acid (21.1%), respectively as empirical therapy. S. aureus and coagulase-negative staphylococci (CNS) strains of oxacillin resistance, respectively (9.9%) and (20%), penicillin resistance (81.8%) and (70%), erythromycin resistance is (72.7%) and (80%), respectively. All gram-positive strains, vancomycin, teicoplanin and linezolid were sensitive to imipenem all gram-negative bacilli, moxifloxacin, levofloxacin and were sensitive to gentamicin.

Conclusion: In this study, S. aureus was the most common bacteria causing infections of the skin detected. High ratio of penicillin and erythromycin resistance was determined in S. aureus and CNS strains.