Lumpy Skin Disease (LSD) is an acute and contagious disease caused by a virus that belongs to Capripox virus genus and characterized by high fever and multifocal nodules on skin in cattle. LSD is endemic in Middle East and Africa causing significant economical losses. In this case report, it was aimed to report LSD infection in a Holstein cattle which was located in the central district of Şırnak City. On 09 May 2014, the owner of the animal reported to the Food, Agriculture and Livestock Directory of Şırnak about the swellings all around his animal's body. After clinical examination, multifocal nodules in several centimeters size on skin and subcutis were found and also in anamnesis anorexia, a decline in milk production and live weight gain were determined. Subcapsular and prefemoral lymph nodes were rather enlarged. Related with these symptoms under the suspicion of LSD, taken defibrinate blood sample was sent to Adana Veterinary Control Institute and nodules obtained from skin were sent to University of Yüzüncü Yıl Veterinary Medicine Faculty Department of Pathology. After the analysis with the Real Time PCR in the molecularbiology laboratory of the Institute, the blood sample were reported as LSD positive. Histopathologically, dermatitis was observed which was characterized by balloon degeneration and hyperplasia in the epithelial cells of the epidermis and hair follicles, acanthosis, multifocal necrosis in the dermis with the infiltration of inflammatory cells, vasculitis and thrombosis. Besides, scattered throughout the inflammation were variable numbers of "sheep pox cells" histiocyte-like cells with large vacuolated nuclei and eosinophilic intracytoplasmic inclusion bodies.

As a result, it is the first time in our country that an LSD infection was diagnosed which was characterized by focal disseminate nodular lesions on the skin and subcutis of a Holstein cattle with its macroscopic and microscopic findings.