The purpose of this case report is to present, for the first time, a case of extensively drug-resistant (XDR) and methicillin-resistant Staphylococcus pseudintermedius (MRSP) in a cat, and to highlight the emergence of XDR-MRSP in companion animals. A three-year-old neutered mixed-breed male cat was presented to the animal hospital with anuria of 24 hours and dysuria, anorexia, and vomiting of approximately six months' duration. Clinical examination revealed high fever (39.6°C), stranguria, and hematuria. Urethrostomy revealed urethral obstruction due to struvite crystals. After culture and antimicrobial susceptibility testing, a feline lower urinary tract infection caused by XDR-MRSP was diagnosed. After treatment with florfenicol, the bacteria were successfully eradicated and clinical signs improved. This report presents the first documented case of XDR-MRSP in a feline patient. This case highlights the possibility of transmission of S. pseudintermedius, a canine commensal, through direct contact with a cat via the pet owner. It also reemphasizes the need for antimicrobial susceptibility testing, continuous monitoring of antimicrobial resistance, and the restriction of antimicrobial use in both humans and animals to limit the spread of XDR-MRSP in communities and hospitals and to establish appropriate treatment a protocol.