Feline polycystic kidney disease is a hereditary disease that effect especially Persian and Persian related cats. In this case report, it is aimed that presenting of the clinical, hematological, biochemical and ultrasonographic findings of chronic renal insufficiency associated with polycystic kidney disease in a Persian cat. A 3 years old, 1.8 kg male Persian cat was presented to Firat University Animal Hospital with a history of 2 week duration polyuria, polydipsia, severe weight loss and vomiting. Chronic renal failure associated with polycystic kidney disease was diagnosed. The supportive treatment was initiated but the cat died after 2 weeks. The necropsy was not performed because of cat’s owner didn’t allow. In conclusion, polycystic kidney disease should be considered in Persian cats that is brought with complaints of vomiting, weight loss, polyuria and polydipsia and it is thought that it may be useful to determine the prevalence of polycystic kidney disease in Persian and other egzotic cats in Turkey.