Facial asymmetry may also be the result of unilateral congenital hypoplasia or aplasia of the depressor anguli oris muscle, which is called as “congenital asymmetric crying facies”; rather than being solely due to facial paralysis. The major finding of the disease is the absence or weakness in the outer and lower movement of the commissure during crying. The other expression muscles are normal and the face is sym¬metric at rest. Additional congenital anomalies related to cardiovascular, cervicofa¬cial, muscle-skeletal, respiratory, and genitourinary or central nervous systems can also accompany the asymmetry in congenital asymmetric crying face. It is diagnosed by physical examination. This paper presents a newborn infant with congenital asymmetric crying face and discusses the case in terms of diagnosis and disease features.