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Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi
2023, Cilt 37, Sayı 3, Sayfa(lar) 188-194
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Protective Effects of Morin Against Acrylamide-Induced Oxidative Stress, Inflammation and Apoptosis in Rat Spleen Tissue: A Biochemical and Histopathological Approach
Nurhan AKARAS1, Fatih Mehmet KANDEMİR2, Hasan ŞİMŞEK3, Sefa KÜÇÜKLER4, Rabia OĞUZ KABAYEL5
1Aksaray Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Ana Bilim Dalı, Aksaray, TÜRKİYE
2Aksaray Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Ana Bilim Dalı, Aksaray, TÜRKİYE
3Aksaray Üniversitesi, Tıp Fakültesi, Fizyoloji Ana Bilim Dalı, Aksaray, TÜRKİYE
4Atatürk Üniversitesi, Veteriner Fakültesi, Biyokimya Ana Bilim Dalı, Erzurum, TÜRKİYE
5Doğuş Üniversitesi, Meslek Yüksekokulu, Tıbbi Laboratuvar Teknikleri, İstanbul, TÜRKİYE
Keywords: Acrylamide, spleen, inflammation, morin, oxidative stress, rat

Acrylamide (ACR) is a chemical monomer with cytotoxic and carcinogenic effects that is formed during heat-induced processing (roasting, baking and frying) of foods with high carbohydrate content, as well as widespread industrial use. Morine (MOR) is a phenolic compound with antioxidant, antiapoptotic and anti-inflammatory properties. This study aimed to examine the effects of MOR against ACR-induced spleen toxicity in an experimental model. In the study, the spleen was evaluated biochemically and histologically in Sprague-Dawley rats that received oral administration of ACR (38.27 mg/kg body weight) and MOR (50 and 100 mg/kg body weight) for 10 consecutive days. The results revealed that MOR exhibited antioxidant properties and increased glutathione (P<0.05) levels with superoxide dismutase (P<0.05), catalase (P<0.05), glutathione peroxidase (P<0.05) activities, and decreased malondialdehyde (P<0.05) levels, which increased with ACR application. In addition, MOR showed anti-inflammatory effect by decreasing the increased levels of NF-κB (P<0.05), IL-1B (P<0.05), TNF-α (P<0.05), and COX-2 (P<0.05) caused by ACR in the spleen tissue, and anti-apoptotic effect by decreasing caspase-3 (P<0.05) levels. MOR also modulated pathological changes, reducing the adverse effects caused by ACR. According to all our findings, it can be expressed that morin has beneficial effects against spleen toxicity induced by experimental acrylamide administration.

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