The objective of this study was to evaluatie serum soluble urokinase plasminogen activator receptor (suPAR), lipopolysaccharide binding protein (LBP), ceruloplasmin and haptoglobin levels in dogs with symptoms of diarrhea infected with Toxocara canis (T. canis). The infected animal animal group consisted of 30 dogs of different genders and breeds, aged 1-6 months, brought to the Department of Internal Medicine of the Kafkas University Faculty of Veterinary Medicine with complaints of anorexia, diarrhea and vomiting, and were diagnosed with T. canis by fecal examination. The control group consisted of 20 dogs at 1-6 month age, that were found to be healthy after clinical and laboratory examination. Blood samples were taken once from infected and healthy dogs for the analysis of hematology and serum biochemistry. The infected animal group had a lower erythrocyte count, hemoglobin concentration, and hematocrit value than the control group (P<0.05). Furthermore, serum suPAR (P<0.001), LBP (P<0.001), ceruloplasmin (P<0.001), and haptoglobin (P=0.003) concentrations in the infected animal group were significantly higher than in the control group. In conclusion, serum suPAR, LBP, ceruloplazmin and haptoglobin levels changed in T. canis-infected puppies with diarrhea. Additionally, not many studies have been found on suPAR and LBP in veterinary medicine. We think that this study will be a source of information for new studies on this subject.