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Fırat Üniversitesi Sağlık Bilimleri Dergisi (Veteriner)
2000, Cilt 14, Sayı 1, Sayfa(lar) 001-006
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Pathological Observation of Experimentally-Induced Cadmium Toxication in Foetal and Neonatal Mouse Pups
Gülçin ÖZTÜRK1, Fethi YILMAZ2
1Veteriner Kontrol ve Araştırma Enstitüsü Müdürlüğü, Elazığ-TÜRKİYE
2Fırat Üniversitesi Sivrice Meslek Yüksekokulu, Elazığ-TÜRKİYE
Keywords: Mouse pups, Cadmium, Experimental toxication, Pathology

In this study, pathological examination was carried out in neonatal and suckling mice taken Cadmium (Cd) from their mother. For this aim, 2.5 mg/kg and 5 mg/kg Cd were added to drinking water of mother mice before and during gestation and lactation periods. These periods were about 60 days. Neonatal and suckling mice of two group were necropsied at the end of these periods. No macroscopic lesions were observed. Degeneration and necrosis of hepatocytes were observed in mice in the group I treated with 2.5 mg/kg Cd. In addition to these findings, megalocytosis in the liver were recorded in mice of the group II treated with 5 mg/kg Cd. Neuronal degeneration in the brain were seen in all experimental groups. Additional findings were hyperemia and epithelial degeneration of tubulus in the kidney in suckling mice. On the other hand, these microscopic lesions were more prominent in mice of the group which were treated with 5 mg/kg Cd.

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