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Fırat Üniversitesi Sağlık Bilimleri Dergisi (Veteriner)
2000, Cilt 14, Sayı 1, Sayfa(lar) 053-060
[ Turkish ]
Investigation of the Effect of Glucose on Acute Arsenic Toxicity
Osman GÜLER1, İzzet KARAHAN2
1Veteriner Kontrol ve Araştırma Enstitüsü, Elazığ-TÜRKİYE
2Fırat Üniversitesi Veteriner Fakültesi, Elazığ-TÜRKİYE
Keywords: Arsenic trioxide, Sodium arsenate, Arsenic levels, Glucose, Rat

This study was carried out to determine the effect of oral glucose application on arsenic levels in liver, kidney and blood samples and on glucose levels in serum samples of rats experimentally poisoned with subcutaneous arsenic administration.

In this study, 390 rats were used. The animals were divided into 10 groups, two control and eight experimental groups. Arsenic trioxide and sodium arsenate were subcutaneous given in the doses 5 and 10 mg/kg into 4 experimental groups. Oral glucose solution (5 %) in addition to arsenic trioxide and sodium arsenate were also given to the remaining experimental groups. Following the administrations, animals were decapitated at 0.5, 1, 2, 4, 8, 12, 24, 48, 72, 96, 120, 168 and 240th hours. Arsenic levels in blood, liver, kidney samples and glucose levels in serum were determined. .

In conclusion, it was observed that arsenic, in greater amounts, passed to liver in rats poisoned with arsenic trioxide, whereas it excessively passed to kidney in rats treated with sodium arsenate. On the other hand, a decrease in serum glucose level was determined due to the disruption of carbohydrate metabolism in acute arsenic poisoning. It was indicated that oral glucose applications might cause a decrease in the liver, and blood arsenic levels, though it might increase kidney arsenic and serum glucose levels in rats. .


[ Turkish ]
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