The aim of this study was to investigate the changes in some biochemical parameters in serum samples of mice, administered with arsenic trioxide and sodium arsenate. Fifty mice at 25-35 g body weight were used in the study. The animals were divided into one control and two experimental groups. Arsenic trioxide and sodium arsenate were given in daily doses of 5 mg As/kg orally with water to experimental groups. During the administrations, in 10, 20, 40, 60 and 90^th days, blood samples were collected. Glucose, aspartate aminotransferase (AST), alanine amino-transferase (ALT), creatinine, albumin, sodium and potassium levels were ascertained in the blood sera.

A significant decrease was observed in serum glucose levels at all periods, in the arsenic trioxide given group. But in the sodium arsenate given group, a decrease in serum glucose was observed after 40^th day. A significant increase in the serum AST and ALT levels were determined in both groups. On the other hand, when compared with control group, no significant changes were observed in serum creatinine, albumin, sodium and potassium levels in the two experimental groups.

In conclusion, in addition to disruption was observed in glucose metabolism, liver and muscle damage was believed to occur in mice treated with arsenic trioxide and sodium arsenate orally for long-term.