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Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi
2009, Cilt 23, Sayı 3, Sayfa(lar) 135-139
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Comperative Evaluation of Collagenase and Silver Sulfadiazine on Burned Wound Healing in Rats
Ali Said DURMUŞ1, Mehmet Cengiz HAN1, İhsan YAMAN2
1Fırat Üniversitesi, Veteriner Fakültesi, Cerrahi Anabilim Dalı, Elazığ, TÜRKİYE
2Fırat Üniversitesi, Sivrice Meslek Yüksekokulu, Elazığ, TÜRKİYE
Keywords: Collagenase, silver sulfadiazine, burn, rat

This experiment was conducted to compare collagenase the effects of ointment and silver sulfadiazine (SSD) on burned wounds for healing in rats. Sixty male Wistar albino rats were divided into three equal groups. A burned model was constituted on the back of all rats. The burned areas in the first, second and third groups were covered daily with collagenase, SSD skin cream and cold cream (control), respectively. Ten and 21 days later the rats were anaesthetized and the burned skin tissue samples of ten cases of each group were collected for histopathological examinations. In conclusion, application of collagenase ointment is significantly effective in healing of burned skin wounds in rat model (P< 0.0001).

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