Tulathromycin is a new product with a lactone ring, a broad spectrum semi-synthetic macrolide. It is administered at a dose of 2.5 mg/kg/bw as single dose subcutaneous in cattle and intramuscular in swine. It is used for the treatment and control of bovine respiratory disease caused Pasteurella haemolytica, Pasteurella multocida, Haemophilus somnus, Actinobacillus pleuropneumonia, Mycoplasma hyopneumonia and Mycoplasma bovis and swine respiratory disease caused Actinobacillus pleuropneumonia, Pasteurella multocida and Mycoplasma hyopneumonia. In this review, general and pharmacological properties of tulathromycin, spectrum of effect, usage, dosage, indication, side effects and toxicity was emphasized in the light of the current literature.