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Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi
2017, Cilt 31, Sayı 1, Sayfa(lar) 021-025
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Comparison of the Effects of Intra-Articular Injections of Bovine Amniotic Fluid and Hyaluronic Acid on Cartilage Tissue in an Experimental Osteoarthritic Rabbit Model: Radiological Findings
Murat TANRISEVER, Sait BULUT
Fırat Üniversitesi, Veteriner Fakültesi, Cerrahi Anabilim Dalı, Elazığ, TÜRKİYE
Keywords: Bovine amniotic fluid, chondroprotective effects, experimental osteoarthritis, hyaluronic acid, radiology

In this experimental study, it was aimed at determining and comparing the effects of bovine amniotic fluid and hyaluronic acid on an osteoarthritis (OA) model induced in the rabbit stifle joints. The study was performed on 21 rabbits undergone anterior cruciate ligament transaction for establishing osteoarthritis. Four weeks later, the rabbits were divided into 3 equal groups of 7 animals each. The first group rabbits received intra articular injection of 0.5 mL bovine amniotic fluid (BAF) three times at one week interval. The second group rabbits were intra articularly injected with 0.5 mL hyaluronic acid (HA) three times at one week interval. The third group rabbits served as control with no application (CONT). All subjects radiographs were taken posterio- anterior and medio- lateral position of the right genu joint before the operation and after the operation at 30, 90 and 120th days. While there were no statistically significant radiographic score differences between the group treated with hyaluronic acid and the group treated with bovine amniotic fluid on 90 and 120th days, the differences compared to the control group were statistically significant (P<0.01). It was concluded that the use of BAF, which is an inert fluid, rich in growth factors had protective effects against cartilage degenerative changes in an experimental rabbit model and it may be therefore an alternative agent to be used in cartilage protective therapy.

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