In this study, it was aimed to determine some hematological and cardiac enzyme activities [cardiac troponin-I (cTn-I), creatine kinase (CK), creatine kinase-myocardial band (CK-MB), lactate dehydrogenase (LDH) and aspartate aminothecenase AST)] and serum A, C and E vitamins with malondialdehyde (MDA) levels in cows with foot-and-mouth diseases. The study material consisted of 20 cattle (patient group) that were diagnosed with foot-and-mouth diseases after general clinical examinations and 20 cattle (vaccination group) with foot-and-mouth vaccination. After detailed clinical examinations (body temperature, heart and respiratory frequency and number of ruminal movements)on days 1, 3, 7 and 14 of the animals in the patient group, before vaccination from the animals in the vaccine group and on the 1st, 3rd, 7th and 14th days after the vaccination (Vaccine-1 group, Vaccine-2 group, Vaccine-3 group and Vaccine-4 group respectively), from V. jugularis according to the procedure for hematological and biochemical analyzes, and blood samples were taken.

The mean values of all clinical parameters between the patient group and the other groups were statistically significantly different (P <0.05). Serum cTn-I and CK levels were found to be significantly higher (P<0.05) in the patient group than in the other groups, while LDH levels was significantly higher in the patient group than in the other groups in terms of mean values of serum AST and CK-MB enzyme activities group and vaccine-1, vaccine-3 and vaccine-4 groups, the difference between the groups was significant at P<0.05 level.

In conclusion, it has been determined that foot-and-mouth disease affects clinical, hematological and cardiac enzyme activities, MDA and vitamins A, C and E significantly. In addition, although not significant, vaccination affected all parameters. It has been concluded that vaccination with A, C and E vitamins would be beneficial.