Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi |
2014, Cilt 28, Sayı 2, Sayfa(lar) 085-088 |
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Investigation of Plasma Concentrations After Topical Administration Selamectin in Sheep and Goats |
Burcu GÜL BAYKALIR, Gürdal DAĞOĞLU |
Fırat Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Elazığ, TÜRKİYE |
Keywords: Selamectin, sheep, goat, HPLC |
The objective of this study was to investigate of plasma concentration and pharmacokinetic
parameters after off-label use of selamectin. One years of ago, 12 ewes and 12 female goats were
used in this study. In both groups, a single dose of 12 mg/kg selamectin (Stronghold® 12% 240
mg) was administered topically. During the 35 days following administration, blood samples were
taken with different intervals and required analyzes were conducted. Plasma concentrations of
selamectin were analysed by high performance liquid chromatography (HPLC). As a result of
analyzes, for sheep mean plasma concentration, maximum plasma concentration (Cmax), the area
under the concentration-time curve (AUC), the mean residence time (MRT) and time to reach peak
concentration (Tmax) values determined as 1427.27±90.52 pg/mL, 4.78±0.61 ng/mL, 810.35±115.95
ng.h/mL, 10.86±0.89 days and 72 hours, respectively and for goats these values were determined
as 1195.03±70.81 pg/mL, 3.27±0.52 ng/mL, 664.42±72.62 ng.h/mL, 10.46±0.74 days and 72
hours, respectively. As a result, plasma concentration, Cmax and AUC values were found higher in
sheep compared to goats (P<0.05) and there was no significant difference between MRT and Tmax
values (P>0.05) using selamectin topically in sheep and goats.
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